Dr Rama Joshi Answers: How Is Uterine Cancer or Endometrial Cancer Treated?

by Team Onco
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Dr Rama Joshi, Director & HOD, Gynae Oncology & Robotic Surgery, Fortis Memorial Research Institute, Gurugram, explains the important aspects of uterine cancer, or endometrial cancer. 

Dr Rama Joshi of Fortis Hospitals explains

Uterine cancer also known as Endometrial cancer starts in the uterus, which is also called the womb. The uterus is a hollow organ, located between the bladder and the rectum. 

Uterine cancer is the most common cancer occurring within a woman’s reproductive system. It occurs when cells in the uterus change and grow out of control, resulting in the formation of a tumour. 

uterine cancer

Am I at risk of developing uterine cancer?

While it is very difficult to predict who will develop uterine cancer and who will not, there are some factors which increase your risk of uterine cancer. Understanding and avoiding these factors can reduce your chances of developing uterine cancer. 

  • Age

Uterine cancer is mostly seen in women over the age of 50. But in some rare cases, even younger women develop uterine cancer. 

  • Obesity

Being overweight and obese increases your risk of developing several diseases, and uterine cancer is one of them. The reason for this is that the fatty tissue in women who are overweight produces more estrogen. Excessive estrogen can increase your risk of uterine cancer. 

  • Diabetes and hypertension

Women who suffer from hypertension and diabetes have a higher risk of developing uterine cancer. Obesity is a risk factor for these diseases as well. 

  • Previous treatments

Women who have had treatments involving tamoxifen have a higher risk of uterine cancer. Tamoxifen is usually prescribed in the treatment of breast cancer. 

  • Unsupervised hormone replacement treatments

Women who have undergone hormone replacement therapy to increase their estrogen levels for prolonged durations or in an unsupervised setting are at higher risk of uterine cancer. 

  • Menstruation and reproduction

Women who started their periods before the age of 12, and those who faced menopause only after the age of 50 are at higher risk of uterine cancer. 

More than the actual age, the gap between these two ages is more indicative of a higher risk. Those who have a longer gap, are at higher risk. 

Women  who have never been pregnant are also at a higher risk. 

Does family history or genetics play a role?

Only about 5% of uterine cancers are due to family history. A family history of uterine or colon cancer may increase your risk of developing uterine cancer. 

Do I have uterine cancer?

The symptoms of uterine cancer can also be the symptoms of other non-cancerous diseases. While the list of symptoms given below can be helpful in detecting uterine cancer, they cannot confirm this. 

With pelvic examination the doctor feels the uterus, vagina, ovaries, and rectum to check for any unusual findings and a transvaginal ultrasound is done to see  pictures of internal organs. If these tests suggest that cancer is present, an endometrial biopsy is performed

Only an endometrial biopsy can confirm uterine cancer. 

If a biopsy confirms the diagnosis, the doctor will order imaging tests such as a CT scan and  MRI. 

It is to be noted that some women with endometrial cancer might not have any symptoms until the disease has spread to other organs.

​​The most common symptom of uterine cancer is abnormal vaginal bleeding. Abnormal vaginal bleeding would include 

  • Bleeding in between menstrual cycles (at times other than during your period), 
  • Menstrual bleeding that is heavier than usual
  • Any vaginal bleeding in a woman who has already gone through menopause

Other symptoms include:

  • Weakness and pain in the lower abdomen, back, or legs. This happens when the cancer has spread to other organs.

If you have one or more of the above symptoms, you should consult your doctor at the earliest.

What does ‘stage’ mean?

As part of your diagnosis, your oncologist will need to find out the stage of your cancer. 

Stage refers to the extent of the spread of the cancer inside your body. 

There are four stages of uterine cancer. 

Stage I indicates that the cancer has not spread outside of the uterus.

Stage II indicates that the tumor has spread from the uterus to the cervical stroma but not to other parts of the body.

Stage III indicates that the cancer has spread beyond the uterus, but it is still only in the pelvic area.

Stage IV indicates that the cancer has spread to other organs like the bladder rectum and/or distant organs.

The treatment for the cancer depends on the stage of the cancer. 

That’s why it’s difficult to start treatment without first conducting a biopsy,  a complete clinical examination including a per vaginal examination and then other imaging studies CT and MRI to find out the stage of the cancer. 

In the biopsy, a small sample of the cancerous tissue is collected and examined. 

The resulting histopathological report and findings of the imaging reports will help your oncologist understand what course of action to take. 

How is uterine cancer treated?

The treatment for uterine cancer will depend a lot on the stage of your cancer. In addition,  treatment will also depend on your age and other medical problems.

The treatment of uterine cancer usually involves surgery, with or without adjuvant therapies like radiation therapy and chemotherapy. 

Surgery

Surgery is the standard treatment for endometrial cancer that has not spread. Surgery involves removal of the uterus along with margins. Margins refer to the surrounding tissues that are also removed during surgery. 

Sometimes the fallopian tubes, and ovaries may also be removed. 

During this surgery, lymph nodes may be removed to check for spread. 

A surgery for uterine cancer needs to be performed by a surgical oncologist or a gynecologic oncosurgeon.

Once the uterus is removed, pregnancy becomes impossible. Your doctor can advise you about the possibility of fertility preservation (especially for women who are young and want to have children in future).

​​Some women will not need further treatment after surgery if surgery removes the cancer. But other women might need further treatment with radiation or chemotherapy or both

Radiation therapy

This is a type of treatment in which high-energy beams are applied on a specific region to target the cancer cells present there. In uterine cancer, radiation is usually offered after surgery depending on the post operative biopsy report. 

Radiation can be provided internally or externally, or both. 

External beam radiation therapy (EBRT) directs the radiation at the cancer and surrounding tissue from outside the body. For cancer of the uterus, the lower abdominal area and pelvis are treated, but if the cancer has spread (metastasised), other areas may also be treated.

 Internal radiation therapy may be used after a hysterectomy to deliver radiation directly to the top of the vagina (vaginal vault) from inside your body. This is known as vaginal vault brachytherapy.

Chemotherapy

Chemotherapy uses drugs to kill or slow the growth of cancer cells. The drugs travel throughout the body through the bloodstream. 

Chemotherapy may be used for 

  • certain types of uterine cancer
  • when cancer comes back after surgery or radiation therapy to try to control the cancer and to relieve symptoms 
  • if the cancer has spread beyond the pelvis when first diagnosed.

What are the side-effects of these treatments?

Cancer treatment does bring with it certain side-effects depending on the type of treatment undergone. 

With surgery, side-effects can include lymphedema (swelling in the legs), menopausal symptoms and loss of fertility. 

Speak to your oncologist about how you can prepare for and manage these symptoms. 

Radiation can cause both short-term and long-term side effects. The short-term side effects may include feeling tired, needing to empty your bladder frequently, discomfort with urination, loose stools, feeling the need to have a bowel movement frequently, and temporary loss of pubic hair. 

In addition to the short-term side effects, which usually resolve after the treatment is over, there can be few  long-term side effects that may not appear until months after treatment is completed. These include increased frequency of urination, irregular bowel movements, narrowing, scarring, and dryness of the vagina.

The most common side effects of chemotherapy include feeling tired, temporary hair loss, nausea and vomiting, diarrhea, low blood counts, menopausal symptoms, like hot flashes, night sweats, and vaginal dryness, numbness and tingling of the fingers and toes (called neuropathy).

To reduce hair loss during chemotherapy, read more about scalp cooling

Watch Dr Rama Joshi’s message for all women here:

 

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