All About Medulloblastoma – The Brain Tumor That Commonly Affects Children

by Dr Amit Jotwani

What is Medulloblastoma?

Medulloblastoma is the most common malignant brain tumour. It is commonly found in children. Nearly 500 US kids get Medulloblastoma every year.

Medulloblastoma-Brain-Tumor Accounting for nearly 20% of all brain tumors in children aged less than 19 years, the peak incidence for this disease occurs in the ages 5-9.


Occurrence, Genetic Susceptibility and Pre-existing Syndromes

A vast majority of Medulloblastoma cases occur sporadically, but hereditary syndromes are also seen in some patients. Such syndromes include:

  • Gorlin Syndrome
  • Blue rubber-bleb nevus syndrome
  • Turcot syndrome

Note: Medulloblastoma is more commonly seen in a male population as compared to females, and carries poor outcomes for male patients

What are the symptoms of Medulloblastoma?

Most Medulloblastoma patients initially present with symptoms and signs of increased intracranial pressure over a period of a few weeks, to a few months.

Other common symptoms include:

  • Morning Headaches
  • Nausea
  • Vomiting
  • Altered Mental Status

Some patients may present symptoms such as abnormality gait, incoordination and limb clumsiness. In some cases, cranial nerve involvement is seen, which may result in double-vision. Infants may also display an increase in head circumference.

Diagnosis of Medulloblastoma

How is Medulloblastoma diagnosed?

When a patient comes and presents symptoms that lead doctors to suspect Medulloblastoma, the following diagnostic tests are advised:

  • Brain CT Scan
  • Brain MRI with Contrast
  • Brain CT Scan
  • Spine MRI
  • CSF Cytology via Lumbar Puncture (A CSF sample is collected from the lumbar region of the spine, using a needle and a syringe.)


Risk Stratification

Patients are classified into two major risk categories, based on three main parameters – age, amount of residual tumor left after surgery, and CSF spread.


  • Standard Risk: Those who undergo a successful tumor removal (complete removal of tumor or cases where the residual tumor is less than 1.5 cm in size) with no evidence of any CSF spread and aged more than 3 years, are categorised within the standard risk group.
  • High Risk: Patients aged less than 3 years, with a residual tumor that is larger than 1.5 cms in size, and with visible evidence of CSF spread, are categorized within the high risk group.

Out of all confirmed Medulloblastoma patients, approximately two-thirds get classified as standard-risk, and the remaining one-third of such patients are categorized as high-risk.

Treatment of Medulloblastoma

What are the treatment options for Medulloblastoma?

Treatment for Medulloblastoma includes general measures to decrease intracranial pressure, followed by specific treatment to fight the tumor.

The three main modalities of treatment applied in Medulloblastoma cases, are SurgeryRadiotherapyand Chemotherapy.


Surgery is a key component in the treatment of medulloblastoma. Whenever possible, maximal safe resection needs to be performed. Surgery helps in decreasing intracranial pressure, confirms the diagnosis, and helps in local control.


Radiation therapy also plays an integral part in the treatment of Medulloblastoma. It is given in order to contain & control residual signs of the disease left after surgery, and to treat disease-spread across the Cranio-Spinal Axis (CSI). The recommended dose of radiation depends on the risk category of the patient.

Note: More recently, newer techniques such as Proton Beam Therapy and/or IMRT are usually recommended, in order to reduce the effect of the radiation dose towards normal (unaffected) structures such as the temporal lobes, inner ears, thyroid gland, heart, lungs and other abdominal organs.


Chemotherapy also plays a significant role in the management of Medulloblastoma. In high-risk patients, Chemotherapy is administered along with Radiotherapy, followed by adjuvant therapy.

In children aged less than 3 years, combination chemotherapy is the initial treatment of choice. This is useful in delaying radiotherapy because exposure to radiation in kids aged less than 3 years can lead to severe neurological impairment.

side effects of chemotherapy

Note: Till date, the treatment for metastatic Medulloblastoma is not completely understood. Many oncologists usually suggest Craniospinal Radiotherapy along with Chemotherapy instead of just radiation.

What is the general outcome for Medulloblastoma patients?

All said and done, it must be noted that Medulloblastoma is an extremely aggressive tumor. Even after good response to surgery and radiation, recurrences/relapses are quite common. Most recurrences of Medulloblastoma cases occur within two years after receiving initial treatment.

  • 5 year survival rate for standard risk patients: 70-80%
  • 5 year survivat rate for high risk patients: 60-70%

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Medical Team @

Medical Team @

The medical team comprises Dr Amit Jotwani, Dr Spoorthi Shelometh, Dr Gurpreet Lamba, and other eminent oncologists, who write for the Newsroom.  Read More



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