Breast Cancer Drugs - Pertuzumab

Pertuzumab (Trade name: Perjeta)

This is an anti-HER2 antibody (Monoclonal Antibody), approved for the treatment of HER2-positive breast cancer, used in combination with Trastuzumab and taxanes in the chemotherapy for breast cancer

Uses or Indications

Pertuzumab is used in the treatment of:

Metastatic HER2 positive breast cancer.
Early HER2 positive breast cancer (as adjuvant or neoadjuvant regime)

Side effects of Pertuzumab

The most commonly known side effects of Pertuzumab include:

Infusion related symptoms like fever, chills, flushing, fatigue, urticaria, headache, etc
Fatigue
Diarrhoea
Nausea and vomiting
Mucositis, stomatitis
Loss of appetite
Decreased left ventricular ejection fraction(LVEF)
Myelosuppression
Alopecia

Availability, administration and dosage of Pertuzumab
Pertuzumab is available as 420 mg/14 ml vials. It is administered intravenously, with the most common regimen as an initial dose of 840 mg given over 60 minutes, followed by a maintenance dose of 420 mg given over 30-60 minutes, every 3 weeks.

Precautions:

Monitor for infusion related symptoms during treatment.
Taxanes should be given after Pertuzumab
Anthracyclines can increase the cardiotoxicity of Pertuzumab
Not advised for pregnant women
Breastfeeding should be avoided while on a Pertuzumab schedule

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