All About Brain Tumor

Everything You Need To Know About Brain Tumor

A brain cancer is an abnormal growth that originates in the brain or a metastatic tumor that has migrated from tumor cells that have originated in other distant parts of the body. It may occur in any tissue contained in the skull, including the brain, the cranial nerves, the meninges, pituitary gland, and the pineal gland.

Doctors diagnose brain tumor by conducting the neurological exam and tests like MRI, CT scan, and biopsy.

Treatment options need to be explored after watchful waiting and they include surgery. Radiotherapy, chemotherapy and targeted therapy. A combination of the different types of treatment procedures is usually prescribed. Read more on Treatment for Brain Cancer here

Patients most commonly present with signs of intracranial pressure (e.g., headache, mood swings, nausea, vomiting and gait abnormality. Read more on Symptoms of Brain Cancer here

According to the National Brain Tumor Society, there are over 120 different types of brain tumors. The most common of which are gliomas that originate in the glial (supportive) tissue. About a third of all primary brain tumors and other nervous system tumors form from glial cells.

Brain_Tumor

Types Of Brain Tumors

There are over 120 different types of brain tumors. The World Health Organization (WHO) developed a classification and grading system to standardize communication across heath networks across the globe. The aim is to plan treatment and predict outcomes more accurately and in an organized fashion.

But based on site of origin, brain tumors are classified into two types:

a. Primary brain tumors originate in brain tissue and tend to stay there.
b. Secondary brain tumors are more common. These cancers start somewhere else in the body and travel to the brain. Lung, breast, kidney, colon, prostate and skin cancers are among the commonest primary cancers that can metastasize to the brain.

Some brain tumors contain cancer cells and others don’t:

  • Benign brain tumors are free from cancer cells. They grow slowly, can definitely be removed, They seldom spread to the surrounding brain tissue. Depending on the location of the tumor, they can be life-threatening.
  • Malignant brain tumors contain cancer cells. The growth rates differ, but cells can invade healthy brain tissue surrounding it. These seldom spread beyond the brain or spinal cord.

Different Types of Brain Tumors

In adults, the most common types of brain cancer are:

  • Astrocytomas. These usually start in the part of the brain that occupies most space the cerebrum. They cause seizures or shifts in behavior.
  • Meningiomas. These are the commonest primary brain tumors in adults. They are most likely to occur in 70s or 80s . They start in the meninges, the lining of the brain. They can be of grades 1, 2, or 3. They are benign and metastasis is rare.
  • Oligodendrogliomas. These arise in the cells that make the covering that protects nerves. They are usually of grades 1, 2, or 3. They usually grow slowly and don’t spread to nearby tissue.

Among children, the most common tumor types are:

  • Medulloblastoma: The tumor usually arises in the cerebellum. It’s sometimes called a primitive neuroectodermal tumor. It is grade IV.
  • Grade I or II astrocytoma: In children, this low-grade tumor occurs anywhere in the brain. The most common astrocytoma among children is juvenile pilocytic astrocytoma. It’s grade I.
  • Ependymoma: The tumor arises from cells that line the ventricles or the central canal of the spinal cord. It’s most commonly found in children and young adults. It can be grade I, II, or III.
  • Brainstem glioma: The tumor occurs in the lowest part of the brain. It can be a low-grade or high-grade tumor. The most common type is diffuse intrinsic pontine glioma.

The common ones of brain tumor are:

1. Gliomas

  • Astrocytoma
  • Pilocytic Astrocytoma (grade I)
  • Diffuse Astrocytoma (grade II)
  • Anaplastic Astrocytoma (grade III)
  • Glioblastoma Multiforme (grade IV)
  • Oligodendroglioma (grade II)
  • Anaplastic Oligodendroglioma (grade III)
  • Ependymoma (grade II)
  • Anaplastic Ependymoma (grade III)

2. Craniopharyngioma

3. Epidermoid

4. Lymphoma

5. Meningioma

6. Schwannoma (neuroma)

7. Pituitary adenoma

8. Pinealoma (pineocytoma, pineoblastoma)

Signs and Symptoms of Brain Tumor

People with a brain tumor may experience either general or specific symptoms.

The symptoms of a brain tumor are:

  • Seizures or paralysis.
  • Headaches.
  • Personality and memory changes.
  • Memory loss and confusion.
  • Nausea and vomiting.
  • Fatigue.
  • Difficulty in swallowing.
  • Changes in vision and other sensory perceptions.

Other symptoms of Brain Tumor:

  • Sleep issues and drowsiness.
  • Changes in ability to walk and conducting daily affairs
  • Balance Issue
  • Facial numbness
  • Depression
  • Trouble with coordinated movement of limbs.

Causes And Risk Factors Of Brain Tumor

A risk factor is that which increases the chance of getting a disease. Most brain tumors are not linked with any known cause. Research studies show the a few risk factors that may raise the risk of developing brain tumors

1. Ionization Radiation

It is a high dose of -rays that can cause cell damage, leading to brain tumor. People exposed to ionization radiation may have increases risk of brain tumors like meningioma or glioma. Read more on types of brain tumors here.

Yet, radiation induced tumors are still very rare.

2. Other Exposure

Exposure to industrial chemicals or solvents is associated with increase in the risk of developing brain tumor. Although there is no conclusive evidence, there is higher risk for individuals who work in oil refining rubber manufacturing and drug manufacturing industries.

3. Family History:

The incidence rate for this is low, and only a small number of families have several members with brain tumors. Von Hippel-Lindau disease, Li-Fraumeni syndrome, and Neurofibromatosis (NF1 and NF2) are inherited conditions found in histories of patient families.

  • Neurofibromatosis type 1 (NF1)

Also known as von Recklinghausen disease, this is the most commonly linked to brain and spinal tumors. People affected gave higher risks of schwannomas, meningiomas, certain types of gliomas and neurofibromas (which are benign tumors of peripheral nerves). Changes in the NF gene cause this disorder. Half the number of cases reported to have been inherited.

  • Neurofibromatosis type 2 (NF2)

Less common than NF1, this condition is linked to vestibular schwannomas (acoustic neuromas), which almost always occur on both sides of the head. It is associated with a raised risk of meningiomas or spinal cord ependymomas. Alterations in the NF2 gene are usually responsible for neurofibromatosis type 2. Half the number of cases reported to have been inherited.

  • Tuberous sclerosis

This condition is caused by TSC1 or TSC2 genes. People affected may have subependymal giant cell astrocytomas (SEGAs), which are low grade astrocytomas that develop beneath the ependymal cells of the ventricles. They may also have other benign tumors of the brain, skin, heart, kidneys, etc.

  • Von Hippel-Lindau disease

Patients affected with this condition tend to develop benign or cancerous tumors in different body parts including hemangioblastomas (benign blood vessel tumors in the brain, spinal cord, retina, inner ear, kidney, adrenal gland and pancreas. Mutations in the VHL gene cause this condition, and it is mostly inherited.

  • Li-Fraumeni syndrome

Patients affected are at a higher risk of developing gliomas along with breast cancer, soft-tissue sarcomas, leukemia, adrenal gland cancer and other types. Mutations in the TP53 gene cause this condition.

  • Other syndromes

Other inherited syndromes linked with brain and spinal tumors are:

– Gorlin syndrome (basal cell nervous syndrome)
– Turcot syndrome
– Cowden syndrome

4. Gender

While there is no rule of thumb for brain tumor in males or females it has been noted that meningiomas are twice as likely to develop in women and medulloblastomas are more frequently reported in men.

5. Age

In general the frequency of brain tumor occurrences in older people is high. The age factor differs according to type and location of cell. For example, adults have a very low risk of developing medulloblastomas, gliomas are most common in adults. The occurrence of meningiomas and craniopharyngiomas are more frequent in adults over the age 50. It is still reported that these tumors may occur at any age.

6. Immunity

Low immunity in people can increase the risk of developing lymphomas in the brain. A weakened immune system may be caused by treatments for other cancers, treatment to prevent rejection of transplanted organs, diSeases like acquired immunodeficiency syndrome (AIDS). Some cases may also be congenital (present at birth).

Brain Tumor Screening Systems And Diagnosis

What are the screening procedures and diagnosis system for Brain tumor?

When the patient presents with suggestive symptoms of brain tumor, the physician will do a thorough medical history and physical examination. Then a plan for screening tests and procedure is drawn out for diagnosis of brain tumor

Your doctor may decide to do some of the following tests:

  • Physical exam
  • Mental assessment
  • Eye exam or eye test
  • Hearing tests
  • Testing your facial muscles
  • Testing your swallowing or gag reflex
  • Checking the strength in your limbs
  • Checking your balance or coordination
  • Checking the sensation on your skin

Imaging for Brain tumor can be done by the following ways:

1. Computed tomography (CT) scan.

A CT scan creates a three-dimensional picture of inside the body using X-rays that are taken from different angles. A special kind of dye is also used to make the image clearer. The dye can be injected into the patient’s veins or can be given as a liquid to swallow. However, even in a CT scan, tumors that are very small are difficult to recognize.

CT angiography (CTA):

Here, the patient is injected with a contrast dye through an IV line while the scanner is at work. This creates detailed images of the blood vessels in the brain helping doctors to plan surgery.

2. Magnetic Resonance Imaging (MRI).

The MRI scan unlike the X-ray uses magnetic waves to give a detailed image of the internal parts of the patient’s body. The MRI is also known to detect the tumor size and a dye called a contrast medium is injected into the patient’s veins to give a more detailed view.

Special types of MRI are as follows:

a. Magnetic resonance angiography (MRA) and venography (MRV)

Used to get images of the blood vessels, this is done during or before surgery.

b. Magnetic resonance spectroscopy

Done as a part of MRI, MRS measures biochemical changes in any area of the brain.

c. Magnetic resonance perfusion

A special type of MR image is taken to determine the amount of blood going to different parts of the brain after a contrast dye injection. This indicates the site of the tumor as a faster growing tumor may need more blood. This in return helps determine which tissues need biopsy to be done.

d. Functional MRI (fMRI)

This test determines the functions different regions of the brain handle so that doctors avoid these regions while planning treatment modalities.

3. Biopsy

A biopsy is a procedure where a sample tissue is removed and looked at under a microscope to see if it is cancerous. Biopsies can be done through different methods like needle biopsy, laparoscopic biopsy and surgical biopsy. For brain tumors, the biopsies are of two types:

a. Stereotactic biopsy

This type of biopsy is done based on imaging tests.

b. Surgical or open biopsy (craniotomy)

If imaging tests confirm that the tumor exists, the neurosurgeon may not do a needle biopsy. Instead he may remove tumorous regions through a surgery called craniotomy. Removing most of the tumor is called debulking.

4. Positron emission tomography (PET) scan

The patient is injected with a mildly radioactive substance (usually a sugar called FDG) and this collects mainly in tumor cells. A camera that is of less quality than CT and MRI scans helps build information for further action.

5. Positron emission tomography (PET) scan

A chest X-ray looks for tumors in the lung if a tumor is found in the brain. This is because many instances of metastasis into the brain have been reported of lung cancers.

6. Electroencephalography

An EEG is used for a measurement of electrical activity of the brain. It also makes it possible to monitor seizures.

7. Evoked potentials.

Like EEG’s, involve electrodes that measure electrical activity; only those of the nerves. They often detect acoustic schwannoma, a noncancerous tumor.

8. Lumbar puncture or spinal tap.

In this procedure, the doctor uses a needle to take sample of cerebrospinal fluid (CSF) to look for tumor cells, blood, or tumor markers.

9. Myelogram

This is used to find if the tumor has spread to the spinal fluid and other parts of the brain.

Different Stages of Brain Tumor

Tumors are graded in accordance with how normal or abnormal the cells appear. Doctors plan treatment based on this observation. Staging also gives them an idea about how fast brain tumor is likely to spread. The following are brain tumor stages.

Grade 1 brain tumors are low grade malignant and slow-growing. It is easy to confuse them with identical healthy cells.

Grade 2 brain tumors are malignant and slow-grading. They have high chance of recurrence and are likely to spread to surrounding tissues.

Grade 3 brain tumors appear abnormal and actively metastasize into surrounding regions of the brain and are very likely to recur.

Grade 4 brain tumors look highly malignant and actively metastasize into surrounding tissues of the brain. Rarely some benign tumors can become malignant and a lower grade tumor may recur with a higher grade.

Brain Tumor Treatment Options

Treatment depends on the type and grade of the cancer, where it is located, its size, and the patient’s age and health. The plan for treatment may involve different types of treatment called a multidisciplinary approach to treatment.

Treatment options and recommendations depend on several factors:

  1. The size, type, and grade of the tumor
  2. Whether the tumor puts pressure on vital parts of the brain
  3. If the tumor has spread to other parts of the CNS or body
  4. Side effects
  5. The patient’s preferences and overall health

Treatment options include those described below, such as surgery, radiation therapy, chemotherapy, targeted and combined therapies.

1. Surgery

Surgery is usually the first segment of treatment. For grade 1 tumors, a surgery may suffice as it is possible to remove the tumor. Otherwise, it is also possible to reduce the size of the tumor and ease symptoms. Read more about surgical complications for brain tumor here.

2. Radiation therapy

Radiotherapy or Radiation Therapy follows surgery to kill any tumor cells that remain in the area. If surgery isn’t an option, radiation therapy alone can also be given. Read more about side effects of radiation therapy for brain tumor here.

3. Chemotherapy

Chemotherapy is used to kill brain cancer cells. It is given orally, via IV, or, less often, in wafers a surgeon places in the brain. Read more about side effects of chemotherapy for brain tumor here.

4. Targeted therapy

can be used to treat only certain types of brain tumors. These drugs attack specific parts of cancer cells and help stop tumors from growing and spreading.

5. Immunotherapy.

Some types of immunotherapy have shown promise in treating brain metastases from lung cancer and melanoma. These include ipilimumab (Yervoy), nivolumab (Opdivo), and pembrolizumab (Keytruda).

6. Combined therapies

Combined therapies are also an option.

Brain cancer is not always easy to treat. If treatment does not prove effective, the disease may be called advanced or terminal. Patients who have advanced brain tumor and who are expected to live less than 6 months, may consider a type of palliative care called hospice care. Read more on palliative care for brain cancer.

Brain Tumor Treatment Follow-up

What is follow-up?

Care for individuals with brain tumor doesn’t end when treatment ends. Follow-up care helps physicians keep on checking to ensure the tumor has not returned, or to deal with any symptoms, and screen the general health of patients.

The care therapy may consist of standard physical examinations, restorative tests, or both. Specialists need to monitor the recuperation in the months and years ahead.

Watching out for recurrence

One objective of follow-up care is to check for a recurrence. A tumor may recur since small portions of tumor cells may stay undetected in the body. After some time, these cells may divide in number until the point they appear on test outcomes or indicate a relapse.

During follow-up care, a specialist acquainted with the medical history can advise a customized follow-up plan in case of a return. A few people may have blood tests or imaging tests done as a component of ordinary follow-up consideration, however testing proposals rely upon a few elements including the type and grade of tumor initially analyzed and the kinds of treatment given.

Many brain tumors may relapse. Therefore, doctors prescribe regular MRI checks.

Alternatives for rehabilitative treatment include:

  1. Language instruction
  2. Word related treatment
  3. Counselling
  4. Medication to reduce fatigue and upgrade memory

The objective of palliative care is to enable individuals to regain health. This is so they stay as free from pain and suffering.

Keeping personal health records

A treatment synopsis helps build a survivorship care plan when treatment is finished. A few survivors follow up with one oncologist, while others fall back on the care of their family specialist. This choice depends on a few variables, including the type and grade of tumor, reactions, medical coverage rules, and personal preference.

It is vital to share the treatment and survivorship care plan with any specialist who is reviewing the case for the first time. These are important pointers for future reference.

Treatment For Recurrent Brain Tumor

What happens if the Brain tumor returns?

Some brain tumors are totally relieved with the first round of treatment. Others will return eventually after they were first treated.

The doctor will be able to the following on further consultation:

  1. monitor the development for some time
  2. help to control the indications of the tumor

Settling on Brain tumor treatment:

The treatment plan will be made exclusively by your multidisciplinary group which will rely upon:

  1. the kind of tumor
  2. the grade and stage of the tumor
  3. the treatment the patient has just had
  4. whether the tumor includes spread inside the cerebrum or spinal string
  5. how fast it is growing
  6. The patient’s general health

Treatment for recurrent Brain tumor:

Surgery

Surgery is a primary treatment modality which attempts to remove as much of the tumor as possible.

In a few cases, it isn’t likely that surgery will help. For instance, if there are a few new brain tumors or if the tumor is presently developing rapidly. It may not be worth putting you through further cerebrum surgery if the tumor is probably going to develop back rapidly a short time later.

Radiotherapy

It may be possible to have radiotherapy if:​

The patient has not had radiotherapy previously
It has occurred a long time since the first tumor

Chemotherapy

Chemotherapy is possible if the brain tumor returns. Regardless of whether the patient was administered chemotherapy treatment previously, there might be another medication or blend of medications that can be administered.

Clinical trials

Specialists need to enhance medicines for individuals whose brain tumor has returned. Consulting with the specialist in the event that you are keen on participating in a clinical preliminary. They can examine through whether there is a reasonable trial for different cases

Support

Discovering that the brain tumor has returned can be stunning and disquieting. A few people find that discussing how they are feeling makes a difference. Care groups, emotional support from family and friends can substantially help patients.

Implants Used in Brain Tumor Treatment

There are more than one type of implants used in the treatment of brain tumor. Some are surgical while the other is a part of radiation therapy.

Surgical Implants

The primary treatment modality for brain cancer is surgery and the following are surgical implants:

A. Shunt: Here a thin tube (called a shunt) is placed in into a ventricle of the brain, through a small hole in the skull. This device moves excess fluid from the brain to another part of the body, such as the abdominal cavity, where it’s absorbed into the bloodstream. A filter catches stray tumor cells that may be in the cerebral spinal fluid (CSF). This procedure can help relieve pressure in the skull
B. Placement of an Ommaya Reservoir: During this brain cancer surgery, a small reservoir attached to a tube under the scalp is implanted. The tubing leads into a ventricle of the brain where the CSF circulates, allowing us to deliver chemotherapy to the brain and CSF, or to remove fluid for biopsy. The reservoir can be removed when it’s no longer needed.

Radiation Implants

Brachytherapy is a kind of treatment for cancers, it puts a radiation appropriately close to the disease tissue. Little radioactive inserts are put into or close to the cerebrum tumor amid surgery. They are otherwise called seeds or pellets. This type of treatment is additionally called interstitial radiation. Brachytherapy is not utilized as regularly as outside radiation to treat cerebrum tumors.

Dangers of Brachytherapy

Dangers include:

  1. Contamination
  2. Seizures
  3. Cerebral pain
  4. Death of close-by tissue (corruption)
  5. Brain swelling

The patient may be awake during this procedure. Provided that this is true, nearby anesthesia may numb the area on the head. Or on the other hand a general anesthesia may be given.

Thin cylinders (catheters) might be set into little gaps in your skull. The radioactive seeds are sent through the catheters into the tumor. The catheters might be evacuated immediately. Or on the other hand they might be left set up until the point that the seeds are evacuated.

The seeds may emit a low dimension of radiation. Guests may need to wear lead smocks or vests. And the patient may need to wear a head protector or stay in the protected room.

A few kinds of low-portion seeds are left set up a couple of months or for all time. These seeds may should be set amid open mind medical procedure (craniotomy).

Drugs Used In The Treatment Of Brain Tumor

Following are the drugs used in the treatment of Brain Tumor

  1. Afinitor (Everolimus)
  2. Bevacizumab
  3. BiCNU (Carmustine)
  4. Gliadel Wafer (Carmustine Implant)
  5. Lomustine
  6. Temozolomide
  7. Irinotecan

Furthermore, drug combinations used in brain tumors:

  • PCV
  • Bevacizumab and Irinotecan

Brain Tumor Prevention

A few lifestyle choices and preferences can help avoid the risk of developing brain tumor . Besides radiation exposure, there is no known cause of brain tumor that is foolproof. However, research has it that general immunity building lifestyle and environmental changes are mandatory. They are:

1. Radiation therapy must be avoided.

If the doctors conclude that the benefits outweigh the risk of developing a brain tumor it can may be given. Generally, pregnant women and children do not get imaging tests like X-rays and CT scans unless the doctors prescribe it.

2. Sleep.

Long-term sleep disruptions may increase the risk of developing cancer.

3. No tobacco.

Staying away from tobacco is probably the best health decision one can make to live a better life. Even exposure to secondhand smoke can affect the body’s general functioning. Furthermore, smoking causes various brain, lung, mouth, laryngeal, pancreatic, bladder, and cervical cancers.

4. Eating right.

Limiting the intake of processed foods, alcohol, salt, and sugars is a good start. Eating vegetables and fruits as well as avoiding obesity are healthy lifestyle routines.

5. Maintaining a safe weight.

As a general goal, there must be at least 30 minutes of physical activity in your daily routine. Exercising per se wards off many disorders and keeps the body going at its optimal best.

6. Protection from the sun.

Avoiding direct rays of sun is also important. Furthermore, use generous amounts of sun protection formulas and avoid tanning lamps and sunlamps (they are just as hazardous as sunlight).

7. Immunization.

Talk to your doctor and check your health chart for any vaccines that you might have missed. Stay proactively secured against diseases is a good forethought.

8. Regular health check-ups.

Self-examinations and screenings are important to stay alert and away from any unforeseen health issues.

9. Knowing your risks and family history.

It is better to be safe than sorry. Stay aware about your genetic history so you can combat any disease before it is too late.

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